2026-41670 - Researcher in Structural Biology / Time-Resolved / Room Temperature Crystallography H/F

Domaine : Biologie, biophysique et biochimie
Contrat : CDD
Description du poste :
Are you passionate about structural biology and the study of enzymatic mechanisms? Join the Institute for Structural Biology (IBS) as a researcher on a 2-year fixed-term contract. You will contribute to the ANR JC Catal-X project by developing a room-temperature kinetic crystallography method (TR-FRX) to visualize enzymes in action. As a researcher, your responsibilities will include: Produce, purify and crystallize proteins of interest, characterize their activity in solution and in crystallo.  Prepare and carry out room-temperature crystallography experiments on the beamline BM07 (ESRF), and on other beamlines if needed. Process and analyze time-resolved diffraction data (data reduction, structure determination, refinement, and analysis of enzymatic mechanisms).

You hold a PhD in structural biology, biophysics, biochemistry or a related field, with strong experience in protein crystallography. Experience in time-resolved crystallography, room-temperature crystallography and structural enzymology would be significant assets. Required skills: protein expression, purification, and crystallization. X-ray diffraction data collection, structure determination and refinement of macromolecular structures. Proficiency with protein crystallography software. Skills in enzymology, UV-Visible absorption spectroscopy and Python would be appreciated. You are autonomous and rigorous, enjoy experimental work, are able to analyze complex data and value collaborative work. ? Why join us? …. By joining the Grenoble Interdisciplinary Institute, you’ll be part of a dynamic and innovative research environment where you’ll have the opportunity to learn, grow and play a key role within a centre of excellence. …AND THAT’S NOT ALL! You may be interested in the benefits that come alongside your main role: A cutting-edge research ecosystem dedicated to topics of significant societal importance. Training to enhance your skills and boost your career. A staff committee offering a wealth of social, cultural and sporting benefits. Practical benefits: staff canteen/meal vouchers, 85% of transport costs covered, and much more. An exceptional living environment in Grenoble, nestled in the mountains, offering a unique balance between city life and nature. ? Want to be part of the adventure? Apply now and put your energy to work for research and innovation! In line with the CEA’s commitments to the integration of people with disabilities, this role is open to everyone. The CEA offers adjustments and/or organisational arrangements to facilitate the inclusion of disabled workers
Ville : Grenoble
Langue / Niveau :
Anglais : Courant
Langue / Niveau :
Français : Intermédiaire